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Wk 3 · 2026

Arizona Cardinals at San Francisco 49ers — Sun, Sep 27

Sun, Sep 27 · Levi's Stadium, Santa Clara, CA · FOX

Weather

No forecast yet. This one is 30 days away. Forecasts reach about 16 days ahead, so this fills in nearer the game. A seasonal average printed here would look exactly like a forecast, which is why there is not one.
Arizona Cardinals
NFC West · no games yet
at
4:05pET
SF -11.5 · total 46.5 DraftKings
Ratings differential SF by 11.2
San Francisco 49ers
NFC West · no games yet

What is at stake

An NFC West game. These two play each other twice a season, home and away, and when the NFC West finishes level it is the head-to-head result and then the division record that separate them — before any of the rest. Division standings.

What the ratings imply

The differential above is arithmetic on two published numbers: The Gridiron King’s 2026 final efficiency ratings, plus 1.7 points of home field. It is not a projection, a value, an edge or a lean, and nothing on this site compares it with the betting line to tell you one is better. Until 2026 games are played it is last season’s measurement of two rosters that have been through a draft and a free-agency window since.

Efficiency · 2026 ratings

Cardinals: -6.8#32
Efficiency margin
49ers: +2.6#7
Cardinals: -3.5#29
Offense
49ers: +2.5#6
Cardinals: -3.4#32
Defense
49ers: +0.2#15
Cardinals: 20.9
Points / game
49ers: 25.7
Cardinals: 28.7
Points allowed / game
49ers: 21.8
Opponent-adjusted ratings from The Gridiron King’s 2026 final numbers. Bars share a scale within each row, so the two lengths are comparable; the brighter side is the better of the two, and a longer bar is the better number — including the rows where a lower figure is the good one. Pace is the exception: it is how fast a team plays, not how well, so neither side is lit and a longer bar there means only more plays.

Team stats

The box-score store these rows are built from has not been produced for this league yet, so no preview carries points and yards for and against. The form, trend and series blocks below are built from this site’s own files and are not affected.

Cardinals form

No completed games on record.

49ers form

No completed games on record.

Cardinals this season

No graded games yet this season. Lines are captured before kickoff and graded when a game goes final, so these records start at Week 1.

49ers this season

No graded games yet this season. Lines are captured before kickoff and graded when a game goes final, so these records start at Week 1.
Lines are captured from ESPN's board before kickoff and locked at kickoff, so an in-play price cannot overwrite the number a game is graded against.

Common opponents · 10

OpponentCardinals49ers
Chargers
AFC
at Wk 1 · scheduled previewat Wk 15 · scheduled preview
Seahawks
NFC
vs Wk 2 · scheduled previewat Wk 5 · scheduled preview
Giants
NFC
at Wk 4 · scheduled previewat Wk 13 · scheduled preview
Rams
NFC
at Wk 6 · scheduled previewN Wk 1 · scheduled preview
Broncos
AFC
vs Wk 7 · scheduled previewvs Wk 4 · scheduled preview
Cowboys
NFC
at Wk 8 · scheduled previewat Wk 10 · scheduled preview
Chiefs
AFC
at Wk 11 · scheduled previewat Wk 16 · scheduled preview
Commanders
NFC
vs Wk 12 · scheduled previewvs Wk 6 · scheduled preview
Eagles
NFC
vs Wk 13 · scheduled previewvs Wk 17 · scheduled preview
Raiders
AFC
vs Wk 17 · scheduled previewvs Wk 9 · scheduled preview
Open these two in the comparison tool for every shared and unshared opponent.

Series history · 2006–2026

Since 2006, 49ers leads 21–19 · 49ers has won the last 2
40 meetings in 2006–2026 · average margin 2.6 points toward 49ers
Yr DateResultSiteWon
20252025-11-1649ers 41 — 22 Cardinalsat ARI49ers
20252025-09-21Cardinals 15 — 16 49ersat SF49ers
20242025-01-0549ers 24 — 47 Cardinalsat ARICardinals
20242024-10-06Cardinals 24 — 23 49ersat SFCardinals
20232023-12-1749ers 45 — 29 Cardinalsat ARI49ers
20232023-10-01Cardinals 16 — 35 49ersat SF49ers
20222023-01-08Cardinals 13 — 38 49ersat SF49ers
20222022-11-2149ers 38 — 10 Cardinalsneutral49ers
20212021-11-07Cardinals 31 — 17 49ersat SFCardinals
20212021-10-1049ers 10 — 17 Cardinalsat ARICardinals
20202020-12-2649ers 20 — 12 Cardinalsat ARI49ers
20202020-09-13Cardinals 24 — 20 49ersat SFCardinals
20192019-11-17Cardinals 26 — 36 49ersat SF49ers
20192019-10-3149ers 28 — 25 Cardinalsat ARI49ers
20182018-10-2849ers 15 — 18 Cardinalsat ARICardinals
20182018-10-07Cardinals 28 — 18 49ersat SFCardinals
20172017-11-05Cardinals 20 — 10 49ersat SFCardinals
20172017-10-0149ers 15 — 18 Cardinalsat ARICardinals
20162016-11-1349ers 20 — 23 Cardinalsat ARICardinals
20162016-10-06Cardinals 33 — 21 49ersat SFCardinals
20152015-11-29Cardinals 19 — 13 49ersat SFCardinals
20152015-09-2749ers 7 — 47 Cardinalsat ARICardinals
20142014-12-28Cardinals 17 — 20 49ersat SF49ers
20142014-09-2149ers 14 — 23 Cardinalsat ARICardinals
20132013-12-2949ers 23 — 20 Cardinalsat ARI49ers
20132013-10-13Cardinals 20 — 32 49ersat SF49ers
20122012-12-30Cardinals 13 — 27 49ersat SF49ers
20122012-10-2949ers 24 — 3 Cardinalsat ARI49ers
20112011-12-1149ers 19 — 21 Cardinalsat ARICardinals
20112011-11-20Cardinals 7 — 23 49ersat SF49ers
20102011-01-02Cardinals 7 — 38 49ersat SF49ers
20102010-11-2949ers 27 — 6 Cardinalsat ARI49ers
20092009-12-14Cardinals 9 — 24 49ersat SF49ers
20092009-09-1349ers 20 — 16 Cardinalsat ARI49ers
20082008-11-1049ers 24 — 29 Cardinalsat ARICardinals
20082008-09-07Cardinals 23 — 13 49ersat SFCardinals
20072007-11-2549ers 37 — 31 Cardinalsat ARI49ers
20072007-09-10Cardinals 17 — 20 49ersat SF49ers
20062006-12-24Cardinals 26 — 20 49ersat SFCardinals
20062006-09-1049ers 27 — 34 Cardinalsat ARICardinals

Cardinals leaders 2025 regular season

PassingJacoby Brissett QB #7315/485, 3366 YDS, 23 TD, 8 INT
Kyler Murray QB #1110/161, 962 YDS, 6 TD, 3 INT
RushingMichael Carter RB #3592 CAR, 333 YDS, 1 TD
Emari Demercado RB #2544 CAR, 312 YDS
Bam Knight RB #2082 CAR, 269 YDS, 4 TD
ReceivingTrey McBride TE #85126 REC, 1239 YDS, 11 TD
Michael Wilson WR #1478 REC, 1006 YDS, 7 TD
Marvin Harrison Jr. WR #1841 REC, 608 YDS, 4 TD
Elijah Higgins TE #8430 REC, 301 YDS
Defense
TacklesBudda Baker S #3120
Akeem Davis-Gaither LB #51117
Jalen Thompson S #3495
SacksJosh Sweat LB #1012
Calais Campbell DE #936.5
Baron Browning LB #52
InterceptionsDenzel Burke CB #293
Dadrion Taylor-Demerson S #422
Budda Baker S #31
full roster and per-player history

49ers leaders 2025 regular season

PassingBrock Purdy QB #13197/284, 2167 YDS, 20 TD, 10 INT
Mac Jones QB #10201/289, 2151 YDS, 13 TD, 6 INT
RushingChristian McCaffrey RB #23311 CAR, 1202 YDS, 10 TD
Brian Robinson Jr. RB #1592 CAR, 400 YDS, 2 TD
Brock Purdy QB #1333 CAR, 147 YDS, 3 TD
ReceivingChristian McCaffrey RB #23102 REC, 924 YDS, 7 TD
Jauan Jennings WR #1455 REC, 643 YDS, 9 TD
George Kittle TE #8557 REC, 628 YDS, 7 TD
Kendrick Bourne WR #1737 REC, 551 YDS
Defense
TacklesDee Winters LB #53101
Tatum Bethune LB #4894
Upton Stout CB #2082
SacksClelin Ferrell DE #984
Bryce Huff DE #474
Sam Okuayinonu DT #913
InterceptionsDeommodore Lenoir CB #22
Ji'Ayir Brown S #272
Dee Winters LB #531
full roster and per-player history
These are regular-season totals for the season named on each card — the players who led that team that year, taken from ESPN's team leaders. That list is keyed to the season, not to today's roster, so a leader who has since signed elsewhere, been traded or retired still appears against the year he earned it; the roster pages and the depth chart on each team page are where the current squad is. A team switches to this season's numbers once it has played a game.