| Player | Pos | Team |
|---|---|---|
| Kenyon Sadiq | TE | New York Jets |
| Mike Sainristil | CB | Washington Commanders |
| Nick Saldiveri | OT | New Orleans Saints |
| Andre' Sam | S | Philadelphia Eagles |
| Nick Samac | C | Minnesota Vikings |
| Drew Sample | TE | Cincinnati Bengals |
| Dylan Sampson | RB | Cleveland Browns |
| Jack Sanborn | LB | Chicago Bears |
| Rigoberto Sanchez | P | Indianapolis Colts |
| Ja'Tavion Sanders | TE | Carolina Panthers |
| Jason Sanders | PK | New York Jets |
| Raheim Sanders | RB | Cleveland Browns |
| Shedeur Sanders | QB | Cleveland Browns |
| T.J. Sanders | DT | Buffalo Bills |
| Jonas Sanker | S | New Orleans Saints |
| Cairo Santos | PK | Chicago Bears |
| Foster Sarell | OT | San Francisco 49ers |
| Elijah Sarratt | WR | Baltimore Ravens |
| Eric Saubert | TE | Seattle Seahawks |
| Treyvhon Saunders | WR | Houston Texans |
| Jonah Savaiinaea | G | Miami Dolphins |
| Jack Sawyer | LB | Pittsburgh Steelers |
| Jacob Saylors | RB | Detroit Lions |
| Ryan Schernecke | OT | New York Giants |
| Austin Schlottmann | C | Tennessee Titans |
| Brenden Schooler | S | New England Patriots |
| Luke Schoonmaker | TE | Dallas Cowboys |
| Cody Schrader | RB | Denver Broncos |
| Billy Schrauth | G | Tampa Bay Buccaneers |
| Dalton Schultz | TE | Houston Texans |
| Carson Schwesinger | LB | Cleveland Browns |
| Ben Scott | G | Tampa Bay Buccaneers |
| Daniel Scott | S | Indianapolis Colts |
| JK Scott | P | Los Angeles Chargers |
| Keionte Scott | CB | Tampa Bay Buccaneers |
| Lucas Scott | FB | Baltimore Ravens |
| Miles Scott | S | Denver Broncos |
| Nick Scott | S | Carolina Panthers |
| Trent Scott | OT | Washington Commanders |
| Tyler Scott | WR | Las Vegas Raiders |
| Zavier Scott | RB | Chicago Bears |
| Nic Scourton | LB | Carolina Panthers |
| Juice Scruggs | G | Detroit Lions |
| Valentin Senn | OT | Arizona Cardinals |
| Trey Sermon | RB | Atlanta Falcons |
| Tim Settle | DT | Washington Commanders |
| Isaac Seumalo | G | Arizona Cardinals |
| Uso Seumalo | DT | Seattle Seahawks |
| Marlen Sewell | S | Chicago Bears |
| Nephi Sewell | LB | Chicago Bears |
| Noah Sewell | LB | Chicago Bears |
| Penei Sewell | OT | Detroit Lions |
| Rashid Shaheed | WR | Seattle Seahawks |
| Khalil Shakir | WR | Buffalo Bills |
| Karson Sharar | LB | Arizona Cardinals |
| Bauer Sharp | TE | Tampa Bay Buccaneers |
| Tyrell Shavers | WR | Buffalo Bills |
| Rodney Shelley | CB | Los Angeles Chargers |
| Coleman Shelton | C | Los Angeles Rams |
| Drew Shelton | OT | Dallas Cowboys |
| Sterling Shepard | WR | New York Jets |
| Nathan Shepherd | DT | New Orleans Saints |
| Will Sheppard | WR | Miami Dolphins |
| Trent Sherfield | WR | Buffalo Bills |
| William Sherman | G | New Orleans Saints |
| Jamien Sherwood | LB | New York Jets |
| Will Shipley | RB | Philadelphia Eagles |
| Tyler Shough | QB | New Orleans Saints |
| Spencer Shrader | PK | Indianapolis Colts |
| Trent Sieg | LS | Dallas Cowboys |
| Zach Sieler | DT | Miami Dolphins |
| Marques Sigle | S | San Francisco 49ers |
| Josh Sills | G | Indianapolis Colts |
| Cam'Ron Silmon-Craig | S | Jacksonville Jaguars |
| Elijah Simmons | DT | Tampa Bay Buccaneers |
| Isaiah Simmons | S | Carolina Panthers |
| Jeffery Simmons | DT | Tennessee Titans |
| Josh Simmons | OT | Kansas City Chiefs |
| Cody Simon | LB | Arizona Cardinals |
| Jaylin Simpson | S | Miami Dolphins |
| John Simpson | G | Baltimore Ravens |
| Trenton Simpson | LB | Baltimore Ravens |
| Ty Simpson | QB | Los Angeles Rams |
| Devin Singletary | RB | New York Giants |
| Alex Singleton | LB | Denver Broncos |
| DeShon Singleton | S | Kansas City Chiefs |
| Nicholas Singleton | RB | Tennessee Titans |
| Ben Sinnott | TE | Washington Commanders |
| Jackson Sirmon | LB | New Orleans Saints |
| Cam Skattebo | RB | New York Giants |
| JL Skinner | S | Denver Broncos |
| Peter Skoronski | G | Tennessee Titans |
| Ben Skowronek | WR | Pittsburgh Steelers |
| Justin Skule | OT | Tampa Bay Buccaneers |
| Jackson Slater | G | Tennessee Titans |
| Rashawn Slater | OT | Los Angeles Chargers |
| Doneiko Slaughter | CB | Pittsburgh Steelers |
| Jake Slaughter | C | Los Angeles Chargers |
| Darius Slayton | WR | Indianapolis Colts |
| Cian Slone | DE | Las Vegas Raiders |
| Kedon Slovis | QB | Green Bay Packers |
| Joey Slye | PK | Tennessee Titans |
| Trey Smack | PK | Green Bay Packers |
| Jabari Small | RB | Detroit Lions |
| Stone Smartt | TE | New Orleans Saints |
| Anthony Smith | WR | Dallas Cowboys |
| Arian Smith | WR | New York Jets |
| Avery Smith | CB | Seattle Seahawks |
| Braden Smith | OT | Houston Texans |
| Brandon Smith | WR | Pittsburgh Steelers |
| Brashard Smith | RB | Kansas City Chiefs |
| Chris Smith | DT | Detroit Lions |
| DeVonta Smith | WR | Philadelphia Eagles |
| DeVonta Smith | CB | Carolina Panthers |
| Genesis Smith | S | Los Angeles Chargers |
| Geno Smith | QB | New York Jets |
| Harrison Smith | S | Minnesota Vikings |
| Jaylin Smith | CB | Houston Texans |
| Jonnu Smith | TE | Green Bay Packers |
| Keidron Smith | DB | Chicago Bears |
| Maason Smith | DT | Atlanta Falcons |
| Roquan Smith | LB | Baltimore Ravens |
| Terell Smith | CB | Pittsburgh Steelers |
| Tim Smith | DT | Indianapolis Colts |
| Tremon Smith | CB | Houston Texans |
| Trey Smith | G | Kansas City Chiefs |
| Tykee Smith | S | Tampa Bay Buccaneers |
| Tyler Smith | G | Dallas Cowboys |
| Tyreke Smith | DE | Kansas City Chiefs |
| Xavier Smith | WR | San Francisco 49ers |
| Za'Darius Smith | DE | Atlanta Falcons |
| Ihmir Smith-Marsette | WR | Carolina Panthers |
| Jaxon Smith-Njigba | WR | Seattle Seahawks |
| Chau Smith-Wade | CB | Carolina Panthers |
| Dawuane Smoot | DE | New York Giants |
| Charlie Smyth | PK | New Orleans Saints |
| Durham Smythe | TE | Baltimore Ravens |
| L'Jarius Sneed | CB | Kansas City Chiefs |
| Charles Snowden | LB | Washington Commanders |
| Javon Solomon | LB | Buffalo Bills |
| Barryn Sorrell | DE | Green Bay Packers |
| Colby Sorsdal | OT | Atlanta Falcons |
| Brevyn Spann-Ford | TE | Dallas Cowboys |
| Tyjae Spears | RB | Tennessee Titans |
| Robert Spears-Jennings | S | Pittsburgh Steelers |
| Ameer Speed | CB | Dallas Cowboys |
| E.J. Speed | LB | Houston Texans |
| Omar Speights | LB | Los Angeles Rams |
| Robert Spillane | LB | New England Patriots |
| Jacob Spomer | C | Los Angeles Chargers |
| Aaron Jones Sr. | RB | Minnesota Vikings |
| Anthony Richardson Sr. | QB | Indianapolis Colts |
| Deebo Samuel Sr. | WR | San Francisco 49ers |
| Gervon Dexter Sr. | DT | Atlanta Falcons |
| James Williams Sr. | LB | Tennessee Titans |
| Kyle Pitts Sr. | TE | Atlanta Falcons |
| Mack Wilson Sr. | LB | Arizona Cardinals |
| Tyrique Stevenson Sr. | CB | Chicago Bears |
| Benjamin St-Juste | CB | Green Bay Packers |
| Nazir Stackhouse | DT | Tennessee Titans |
| Matthew Stafford | QB | Los Angeles Rams |
| Isaiah Stalbird | LB | New Orleans Saints |
| Ronnie Stanley | OT | Baltimore Ravens |
| Malaki Starks | S | Baltimore Ravens |
| Carson Steele | RB | Philadelphia Eagles |
| Terence Steele | OT | Dallas Cowboys |
| Tyler Steen | G | Philadelphia Eagles |
| Beau Stephens | G | Seattle Seahawks |
| Brandon Stephens | CB | New York Jets |
| Drew Stevens | PK | Washington Commanders |
| Rhamondre Stevenson | RB | New England Patriots |
| Reddy Steward | CB | Dallas Cowboys |
| Grover Stewart | DT | Indianapolis Colts |
| Josaiah Stewart | LB | Los Angeles Rams |
| M.J. Stewart | S | Houston Texans |
| Shemar Stewart | DE | Cincinnati Bengals |
| Easton Stick | QB | Tampa Bay Buccaneers |
| Jarrett Stidham | QB | Denver Broncos |
| Qwan'tez Stiggers | CB | New York Jets |
| Tarheeb Still | CB | Los Angeles Chargers |
| Ben Stille | DT | Detroit Lions |
| Dante Stills | DT | Arizona Cardinals |
| Aaron Stinnie | G | New York Giants |
| Eric Stokes | CB | Las Vegas Raiders |
| Chris Stoll | LS | Seattle Seahawks |
| Jack Stoll | TE | San Francisco 49ers |
| Geno Stone | S | Buffalo Bills |
| Jordan Stout | P | New York Giants |
| Upton Stout | CB | San Francisco 49ers |
| Cade Stover | TE | Houston Texans |
| Eli Stowers | TE | Philadelphia Eagles |
| Jack Strand | QB | Atlanta Falcons |
| Brenton Strange | TE | Jacksonville Jaguars |
| Cole Strange | G | Los Angeles Chargers |
| Kentavius Street | DT | Chicago Bears |
| De'Zhaun Stribling | WR | San Francisco 49ers |
| Danny Striggow | DE | Jacksonville Jaguars |
| Justin Strnad | LB | Denver Broncos |
| Jalen Stroman | S | San Francisco 49ers |
| Dorian Strong | CB | Buffalo Bills |
| C.J. Stroud | QB | Houston Texans |
| Grant Stuard | LB | Los Angeles Rams |
| Treydan Stukes | S | Las Vegas Raiders |
| J. Michael Sturdivant | WR | Green Bay Packers |
| Danny Stutsman | LB | New Orleans Saints |
| Sonny Styles | LB | Washington Commanders |
| Kingsley Suamataia | OT | Kansas City Chiefs |
| Jay'viar Suggs | DT | New Orleans Saints |
| Rex Sunahara | LS | Cleveland Browns |
| Jalen Sundell | C | Seattle Seahawks |
| Chazz Surratt | LB | Seattle Seahawks |
| Courtland Sutton | WR | Denver Broncos |
| Evan Svoboda | TE | Los Angeles Chargers |
| Josh Sweat | LB | Arizona Cardinals |
| Montez Sweat | DE | Chicago Bears |
| T'Vondre Sweat | DT | New York Jets |
| D'Andre Swift | RB | Chicago Bears |
| Khordae Sydnor | DE | Cleveland Browns |
| Andre Szmyt | PK | Cleveland Browns |